Zyban 150mg SR Tablets 30
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Use: Adjunct treatment of nicotine dependence in adults > 18 years
Bupropion is a selective inhibitor of the neuronal reuptake of catecholamines (noradrenaline and dopamine) with minimal effect on the reuptake of indolamines (serotonin) and no inhibitory effect on monoamine oxidase. The mechanism by which bupropion enhances the ability of patients to abstain from smoking is unknown. However, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms. In clinical trials, treatment with Zyban reduced withdrawal symptoms compared to placebo and there was evidence of reduction in craving for cigarettes or urge to smoke compared to placebo.
May be taken with or without food. Commence while still smoking; set target quit date for 2nd week of treatment. Initially 150 mg daily for 3 days, then 150 mg twice daily (at a min interval of 8 hrs) for at least 7 weeks
Zyban may affect the abili